INTERA has won a 3-year contract with the Swiss National Cooperative for the Disposal of Radioactive Waste (Nagra) to conduct model-based assessments of the impact of repository-induced effects on the long-term performance of repository systems. The work will examine two repository types—high-level waste (HLW) and low-and intermediate-level waste (L/ILW)—and is aimed at determining whether site specific aspects may exhibit a significant impact on the safety margins associated with the mitigation of repository-induced effects. The role of the repository-induced effects will be evaluated by conducting thermo-hydraulic simulations of two phase flow and multi-component transport along the backfilled repository configurations and in the surrounding host rock in 2-dimensional and 3-dimensional model set-ups. The simulations will cover the entire lifecycle of the repositories, including construction, operations, and post-closure.